Project 1: Oxidative DNA damage and its contribution to metabolic health
Simon H, Vartanian V, Wong MH, Nakabeppu Y, Sharma P, Lloyd RS, Sampath H. OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model. PLoS One. 2020. 15(1):e0227501.
Sampath H and Lloyd RS. Roles of OGG1 in transcriptional regulation and maintenance of metabolic homeostasis. DNA Repair. 2019 81:102667.
Sharma P and Sampath H. Mitochondrial DNA Integrity: Role in Health and Disease. Cells 2019, 8(2), 100. (invited review)
Komakula SSB, Tumova J, Kumaraswamy D, Burchat N, Vartanian V, Ye H, Dobrzyn A, Lloyd RS, and Sampath H. The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue. Scientific Reports. 2018; 8(1):14886.
Vartanian V, Tumova J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd RS, and Sampath H. 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. PLoS One. 2017. PLoS One. 2017. 12:e0181687.
Sampath H. Phenotypes of base excision repair deficient models. Environmental and Molecular Mutagenesis. 2014
Sampath H, Vartanian V, Rollins R, Sakumi K, Nakabeppu Y, Lloyd RS. 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction. PLoS ONE. 2012 7:E51697.
Sampath H, McCullough AK, Lloyd RS. Regulation of DNA glycosylases and their role in limiting disease. Free Radic. Res. 2012 46:460-78.
Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK, Lloyd RS. Variable penetrance of metabolic phenotypes and development of high fat diet-induced adiposity in neil1-deficient mice. Am J Physiol Endocrinol Metab. 2011 300:E724-34.
Project 2: The impact of lipid desaturation on energy homeostasis
Sampath H and Ntambi JM. The role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014 289:2482-8.
Sampath H and Ntambi JM. The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann NY Acad Sci. 2011 1243: 47-53.
Sampath H, Flowers MT, Liu X, et al. Skin-specific deletion of Stearoyl-CoA Desaturase-1 alters skin lipid composition and protects mice from high-fat diet-induced obesity. J Biol Chem. 2009 284:19961-73.
Miyazaki M, Flowers MT, Sampath H et al. Hepatic Stearoyl-CoA Desaturase-1 Deficiency Protects Mice from Carbohydrate-Induced Adiposity and Hepatic Steatosis. Cell Metab. 2007 6:484-96.
Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 2007 282: 2483-93.